2j9x Summary

pdbe.org/2j9x
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TRYPTOPHAN SYNTHASE IN COMPLEX WITH GP, ALPHA-D,L-GLYCEROL-PHOSPHATE, CS, PH6.5 - ALPHA AMINOACRYLATE FORM - (GP)E(A-A)

The structure was published by Ngo, H., Kimmich, N., Harris, R., et al., Barends, T.R., Schlichting, I., and Dunn, M.F., in 2007 in a paper entitled "Allosteric Regulation of Substrate Channeling in Tryptophan Synthase: Modulation of the L-Serine Reaction in Stage I of the Beta-Reaction by Alpha-Site Ligands." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely TRYPTOPHAN SYNTHASE ALPHA CHAIN and TRYPTOPHAN SYNTHASE BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TRYPTOPHAN SYNTHASE ALPHA CHAIN P00929 (1-268) (TRPA_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 99% 268 98%
B TRYPTOPHAN SYNTHASE BETA CHAIN P0A2K1 (2-397) (TRPB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 98% 396 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00929 (1 - 268) TRYPTOPHAN SYNTHASE ALPHA CHAIN Salmonella enterica subsp. enterica serovar Typhimurium
P0A2K1 (2 - 397) TRYPTOPHAN SYNTHASE BETA CHAIN Salmonella enterica subsp. enterica serovar Typhimurium

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00929) Tryptophan biosynthesis enzymessearch Aldolase class Isearch PF00290: Tryptophan synthase alpha chainsearch
B (P0A2K1) Tryptophan synthase beta subunit-like PLP-dependent enzymessearch PF00291: Pyridoxal-phosphate dependent enzymesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P00929) tryptophan metabolic processsearch metabolic processsearch cellular amino acid biosynthetic processsearch tryptophan biosynthetic processsearch aromatic amino acid family biosynthetic processsearch catalytic activitysearch tryptophan synthase activitysearch protein bindingsearch lyase activitysearch
B (P0A2K1) tryptophan biosynthetic processsearch tryptophan metabolic processsearch cellular amino acid biosynthetic processsearch aromatic amino acid family biosynthetic processsearch protein bindingsearch tryptophan synthase activitysearch lyase activitysearch

Chain InterPro annotation
A Tryptophan synthase, alpha chainsearch Ribulose-phosphate binding barrelsearch Aldolase-type TIM barrelsearch Tryptophan synthase, alpha chain, active sitesearch
B Tryptophan synthase beta subunit-like PLP-dependent enzymesearch Tryptophan synthase, beta chain, conserved sitesearch Tryptophan synthase, beta chainsearch Tryptophan synthase beta chain/beta chain-likesearch