› 2j5w

X-ray diffraction
2.8Å resolution

Ceruloplasmin revisited: structural and functional roles of various metal cation binding sites

Released:
DOI: 10.2210/pdb2j5w/pdb
PDB entry 2j5w coloured by chain, front view.
PDB entry 2j5w coloured by chain, side view.
PDB entry 2j5w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ceruloplasmin revisited: structural and functional roles of various metal cation-binding sites.
Bento I, Peixoto C, Zaitsev VN, Lindley PF
Acta Crystallogr D Biol Crystallogr 63 240-8 (2007)
PMID: 17242517

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132511 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ceruloplasmin Chain: A
Molecule details ›
Chain: A
Length: 1065 amino acids
Theoretical weight: 122.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00450 (Residues: 1-1065; Coverage: 100%)
Gene name: CP
Sequence domains:
Structure domains: Cupredoxins - blue copper proteins

Ligands and Environments

7 bound ligands:
Ligand CA 1 x CA
Ligand NA 3 x NA
Ligand CU 7 x CU
Ligand O 1 x O
Ligand OXY 1 x OXY
Ligand NAG 2 x NAG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3221
Unit cell:
a: 209.14Å b: 209.139Å c: 82.752Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.175 0.226

Quick links

Citations

8 review citations

Iron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy.
McCarthy et al. (2015)
7 more

14 mentions without citation

Copper active sites in biology.
Solomon et al. (2014)
13 more