2j59 Summary

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CRYSTAL STRUCTURE OF THE ARF1:ARHGAP21-ARFBD COMPLEX

The structure was published by Menetrey, J., Perderiset, M., Cicolari, J., et al., Franco, M., Chavrier, P., and Houdusse, A., in 2007 in a paper entitled "Structural Basis for Arf1-Mediated Recruitment of Arhgap21 to Golgi Membranes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ADP-RIBOSYLATION FACTOR 1 and RHO-GTPASE ACTIVATING PROTEIN 10.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ADP-RIBOSYLATION FACTOR 1 P84078 (18-181) (ARF1_MOUSE)search Mus musculussearch 91% 166 99%
B ADP-RIBOSYLATION FACTOR 1 P84078 (18-181) (ARF1_MOUSE)search Mus musculussearch 91% 166 99%
C ADP-RIBOSYLATION FACTOR 1 P84078 (18-181) (ARF1_MOUSE)search Mus musculussearch 91% 166 99%
D ADP-RIBOSYLATION FACTOR 1 P84078 (18-181) (ARF1_MOUSE)search Mus musculussearch 91% 166 99%
E ADP-RIBOSYLATION FACTOR 1 P84078 (18-181) (ARF1_MOUSE)search Mus musculussearch 91% 166 99%
F ADP-RIBOSYLATION FACTOR 1 P84078 (18-181) (ARF1_MOUSE)search Mus musculussearch 91% 166 99%
M RHO-GTPASE ACTIVATING PROTEIN 10 Q5T5U3 (929-1096) (RHG21_HUMAN)search Homo sapienssearch < 90% 168 67%
N RHO-GTPASE ACTIVATING PROTEIN 10 Q5T5U3 (929-1096) (RHG21_HUMAN)search Homo sapienssearch < 90% 168 67%
O RHO-GTPASE ACTIVATING PROTEIN 10 Q5T5U3 (929-1096) (RHG21_HUMAN)search Homo sapienssearch < 90% 168 67%
P RHO-GTPASE ACTIVATING PROTEIN 10 Q5T5U3 (929-1096) (RHG21_HUMAN)search Homo sapienssearch < 90% 168 67%
Q RHO-GTPASE ACTIVATING PROTEIN 10 Q5T5U3 (929-1096) (RHG21_HUMAN)search Homo sapienssearch < 90% 168 67%
R RHO-GTPASE ACTIVATING PROTEIN 10 Q5T5U3 (929-1096) (RHG21_HUMAN)search Homo sapienssearch < 90% 168 67%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P84078 (18 - 181) ADP-RIBOSYLATION FACTOR 1 Mus musculus
Q5T5U3 (929 - 1096) RHO-GTPASE ACTIVATING PROTEIN 10 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F (P84078) G proteinssearch P-loop containing nucleotide triphosphate hydrolasessearch PF00025: ADP-ribosylation factor familysearch
M, N, O, P, Q, R Pleckstrin-homology domain (PH domain)search PH domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C, D, E, F (P84078) endomembrane systemsearch synapsesearch Golgi apparatussearch intracellularsearch cell junctionsearch plasma membranesearch neuron projectionsearch perinuclear region of cytoplasmsearch cytosolsearch sarcomeresearch extracellular vesicular exosomesearch postsynaptic membranesearch membranesearch postsynaptic densitysearch cytoplasmsearch transportsearch small GTPase mediated signal transductionsearch vesicle-mediated transportsearch protein transportsearch cellular copper ion homeostasissearch long term synaptic depressionsearch dendritic spine organizationsearch regulation of receptor internalizationsearch regulation of Arp2/3 complex-mediated actin nucleationsearch GTP bindingsearch protein bindingsearch poly(A) RNA bindingsearch nucleotide bindingsearch
M, N, O, P, Q, R (Q5T5U3) phospholipid bindingsearch

Chain InterPro annotation
A, B, C, D, E, F Small GTP-binding protein domainsearch Small GTPase superfamily, ARF/SAR typesearch Small GTPase superfamily, ARF typesearch P-loop containing nucleoside triphosphate hydrolasesearch
M, N, O, P, Q, R Pleckstrin homology domain, spectrin-typesearch Pleckstrin homology domainsearch Pleckstrin homology-like domainsearch