2j4z Summary

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STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-680626

The structure was published by Fancelli, D., Moll, J., Varasi, M., et al., Tonani, R., Zugnoni, P., and Vianello, P., in 2006 in a paper entitled "1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of SERINE THREONINE-PROTEIN KINASE 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE THREONINE-PROTEIN KINASE 6 O14965 (100-403) (AURKA_HUMAN)search Homo sapienssearch < 90% 306 88%
B SERINE THREONINE-PROTEIN KINASE 6 O14965 (100-403) (AURKA_HUMAN)search Homo sapienssearch < 90% 306 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (100 - 403) SERINE THREONINE-PROTEIN KINASE 6 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (O14965) ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch