2j14 Summary

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3,4,5-TRISUBSTITUTED ISOXAZOLES AS NOVEL PPARDELTA AGONISTS: PART2

The structure was published by Epple, R., Azimioara, M., Russo, R., et al., Saez, E., Seidel, H.M., and Tian, S.S., in 2006 in a paper entitled "3,4,5-Trisubstituted Isoxazoles as Novel Ppardelta Agonists. Part 2" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA Q03181 (165-441) (PPARD_HUMAN)search Homo sapienssearch < 90% 285 89%
B PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA Q03181 (165-441) (PPARD_HUMAN)search Homo sapienssearch < 90% 285 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q03181 (165 - 441) PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q03181) steroid hormone receptor activitysearch DNA bindingsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Peroxisome proliferator-activated receptor, betasearch Nuclear hormone receptor, ligand-bindingsearch