2j0m Summary


Crystal structure a two-chain complex between the FERM and kinase domains of focal adhesion kinase.

The structure was published by Lietha, D., Cai, X., Li, Y., Schaller, M.D., and Eck, M.J., in 2007 in a paper entitled "Structural Basis for the Autoinhibition of Focal Adhesion Kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely FOCAL ADHESION KINASE 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FOCAL ADHESION KINASE 1 Q00944 (31-399) (FAK1_CHICK)search Gallus gallussearch < 90% 371 88%
B FOCAL ADHESION KINASE 1 Q00944 (411-686) (FAK1_CHICK)search Gallus gallussearch < 90% 276 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q00944 (31 - 399) FOCAL ADHESION KINASE 1 Gallus gallus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Second domain of FERMsearch, Third domain of FERMsearch, First domain of FERMsearch FERM central domainsearch
B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q00944) cytoskeletonsearch
B (Q00944) ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A FERM domainsearch FERM/acyl-CoA-binding protein, 3-helical bundlesearch FERM central domainsearch Band 4.1 domainsearch Ubiquitin-related domainsearch
B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch