Assemblies
Assembly Name:
Focal adhesion kinase 1
Multimeric state:
hetero dimer
Accessible surface area:
29319.43 Å2
Buried surface area:
2199.43 Å2
Dissociation area:
646.18
Å2
Dissociation energy (ΔGdiss):
-7.37
kcal/mol
Dissociation entropy (TΔSdiss):
13.04
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-169485
Macromolecules
Chain: A
Length: 371 amino acids
Theoretical weight: 42.44 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Pfam:
InterPro:
Length: 371 amino acids
Theoretical weight: 42.44 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q00944 (Residues: 31-399; Coverage: 35%)
Pfam:
InterPro:
- Band 4.1 domain
- Ubiquitin-like domain superfamily
- FERM domain
- Focal adhesion kinase, N-terminal
- FERM/acyl-CoA-binding protein superfamily
- FERM superfamily, second domain
- FERM central domain
- PH-like domain superfamily
- FAK1/PYK2, FERM domain C-lobe
- Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
- Acyl-CoA Binding Protein
- Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Chain: B
Length: 276 amino acids
Theoretical weight: 31.76 KDa
Source organism: Gallus gallus
Expression system: Trichoplusia ni
UniProt:
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
Length: 276 amino acids
Theoretical weight: 31.76 KDa
Source organism: Gallus gallus
Expression system: Trichoplusia ni
UniProt:
- Canonical: Q00944 (Residues: 411-686; Coverage: 26%)
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
- Protein kinase-like domain superfamily
- Protein kinase domain
- Serine-threonine/tyrosine-protein kinase, catalytic domain
- Tyrosine-protein kinase, catalytic domain
- Protein kinase, ATP binding site
- Tyrosine-protein kinase, active site
