2j0l Summary

pdbe.org/2j0l
spacer

CRYSTAL STRUCTURE OF A THE ACTIVE CONFORMATION OF THE KINASE DOMAIN OF FOCAL ADHESION KINASE WITH A PHOSPHORYLATED ACTIVATION LOOP.

The structure was published by Lietha, D., Cai, X., Ceccarelli, D.F.J., Li, Y., Schaller, M.D., and Eck, M.J., in 2007 in a paper entitled "Structural Basis for the Autoinhibition of Focal Adhesion Kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of FOCAL ADHESION KINASE 1. This molecule has the UniProt identifier Q00944 (FAK1_CHICK)search. The sample contained 276 residues which is < 90% of the natural sequence. Out of 276 residues 276 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FOCAL ADHESION KINASE 1 Q00944 (411-686) (FAK1_CHICK)search Gallus gallussearch < 90% 276 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q00944 (411 - 686) FOCAL ADHESION KINASE 1 Gallus gallus

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (Q00944) protein phosphorylationsearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch