2izv Summary

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CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION

The structure was published by Bullock, A.N., Rodriguez, M.C., Debreczeni, J.E., Songyang, Z., and Knapp, S., in 2007 in a paper entitled "Structure of the Socs4-Elonginb/C Complex Reveals a Distinct Socs Box Interface and the Molecular Basis for Socs-Dependent Egfr Degradation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.55 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely SUPPRESSOR OF CYTOKINE SIGNALING 4, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, and TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SUPPRESSOR OF CYTOKINE SIGNALING 4 Q8WXH5 (274-437) (SOCS4_HUMAN)search Homo sapienssearch < 90% 187 87%
B TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 Q15370 (1-118) (ELOB_HUMAN)search Homo sapienssearch 100% 118 88%
C TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1 Q15369 (17-112) (ELOC_HUMAN)search Homo sapienssearch 100% 97 87%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8WXH5 (274 - 437) SUPPRESSOR OF CYTOKINE SIGNALING 4 Homo sapiens
Q15370 (1 - 118) TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 Homo sapiens
Q15369 (17 - 112) TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SOCS box-likesearch, SH2 domainsearch SH2 domainsearch, SOCS boxsearch
B (Q15370) Ubiquitin-relatedsearch Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1search PF00240: Ubiquitin familysearch
C (Q15369) BTB/POZ domainsearch Potassium Channel Kv1.1; Chain Asearch PF03931: Skp1 family, tetramerisation domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q8WXH5) intracellular signal transductionsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch negative regulation of epidermal growth factor-activated receptor activitysearch
B (Q15370) transcription elongation from RNA polymerase II promotersearch viral processsearch protein complex assemblysearch transcription, DNA-templatedsearch transcription from RNA polymerase II promotersearch cellular response to hypoxiasearch regulation of transcription, DNA-templatedsearch protein ubiquitinationsearch positive regulation of viral transcriptionsearch regulation of transcription from RNA polymerase II promoter in response to hypoxiasearch gene expressionsearch nucleoplasmsearch cytosolsearch extracellular vesicular exosomesearch Cul2-RING ubiquitin ligase complexsearch elongin complexsearch Cul5-RING ubiquitin ligase complexsearch nucleussearch protein bindingsearch ubiquitin protein ligase bindingsearch
C (Q15369) ubiquitin-dependent protein catabolic processsearch

Chain InterPro annotation
A SH2 domainsearch SOCS protein, C-terminalsearch Suppressor of cytokine signallingsearch Suppressor of cytokine signalling 4search
B Ubiquitin-likesearch Ubiquitin-related domainsearch
C SKP1 componentsearch BTB/POZ foldsearch SKP1 component, POZ domainsearch