› 2ixn

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa2 PTPA2

Released:
DOI: 10.2210/pdb2ixn/pdb
PDB entry 2ixn coloured by chain, front view.
PDB entry 2ixn coloured by chain, side view.
PDB entry 2ixn coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
Leulliot N, Vicentini G, Jordens J, Quevillon-Cheruel S, Schiltz M, Barford D, van Tilbeurgh H, Goris J
Mol Cell 23 413-24 (2006)
PMID: 16885030

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein phosphatase 2A activator 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 310 amino acids
Theoretical weight: 36.34 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12461 (Residues: 1-309; Coverage: 86%)
Gene names: NOH1, RRD2, YPA2, YPL152W
Sequence domains: Phosphotyrosyl phosphate activator (PTPA) protein
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2221
Unit cell:
a: 157.93Å b: 171.042Å c: 53.735Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.273
Expression system: Escherichia coli

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Citations

11 review citations

Serine/threonine phosphatases: mechanism through structure.
Shi Y. (2009)
10 more