2iw9 Summary

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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR

The structure was published by Pratt, D.J., Bentley, J., Jewsbury, P., Boyle, F.T., Endicott, J.A., and Noble, M.E.M., in 2006 in a paper entitled "Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN-A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 302 97%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 302 97%
B CYCLIN-A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 98%
D CYCLIN-A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN-A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P24941) protein phosphorylationsearch DNA repairsearch mitotic G2 phasesearch positive regulation of cell proliferationsearch mitotic cell cyclesearch cell divisionsearch centrosome duplicationsearch G2/M transition of mitotic cell cyclesearch DNA replicationsearch G1/S transition of mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cellular response to DNA damage stimulussearch regulation of gene silencingsearch blood coagulationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to nitric oxidesearch cell cyclesearch histone phosphorylationsearch positive regulation of DNA-dependent DNA replication initiationsearch potassium ion transportsearch mitotic nuclear divisionsearch positive regulation of transcription, DNA-templatedsearch mitotic G1 DNA damage checkpointsearch meiotic nuclear divisionsearch Ras protein signal transductionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch phosphorylationsearch protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch protein bindingsearch histone kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch metal ion bindingsearch transferase activitysearch nucleotide bindingsearch nucleoplasmsearch nucleussearch cytosolsearch X chromosomesearch Cajal bodysearch centrosomesearch cytoskeletonsearch endosomesearch microtubule organizing centersearch cytoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch condensed chromosomesearch Y chromosomesearch transcription factor complexsearch
B, D (P20248) regulation of cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch protein kinase bindingsearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch