2iw9 Summary

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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR

The structure was published by Pratt, D.J., Bentley, J., Jewsbury, P., Boyle, F.T., Endicott, J.A., and Noble, M.E.M., in 2006 in a paper entitled "Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN-A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 302 97%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 302 97%
B CYCLIN-A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 98%
D CYCLIN-A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN-A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch histone kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch kinase activitysearch transferase activitysearch metal ion bindingsearch nucleotide bindingsearch G2/M transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch G1/S transition of mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch Ras protein signal transductionsearch potassium ion transportsearch meiotic nuclear divisionsearch protein phosphorylationsearch mitotic nuclear divisionsearch centrosome duplicationsearch histone phosphorylationsearch cell divisionsearch positive regulation of transcription, DNA-templatedsearch positive regulation of cell proliferationsearch mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch DNA replicationsearch phosphorylationsearch cellular response to nitric oxidesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch blood coagulationsearch DNA repairsearch cellular response to DNA damage stimulussearch regulation of gene silencingsearch cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch nucleoplasmsearch cytosolsearch microtubule organizing centersearch endosomesearch nucleussearch centrosomesearch transcription factor complexsearch cytoskeletonsearch cyclin-dependent protein kinase holoenzyme complexsearch Cajal bodysearch cytoplasmsearch X chromosomesearch chromosome, telomeric regionsearch condensed chromosomesearch Y chromosomesearch
B, D (P20248) protein kinase bindingsearch regulation of cell cyclesearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch