2iw6 Summary

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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR

The structure was published by Pratt, D.J., Bentley, J., Jewsbury, P., Boyle, F.T., Endicott, J.A., and Noble, M.E.M., in 2006 in a paper entitled "Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN-A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 302 98%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 302 98%
B CYCLIN-A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 98%
D CYCLIN-A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN-A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch metal ion bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch transferase activitysearch cyclin bindingsearch histone kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch mitotic nuclear divisionsearch DNA repairsearch histone phosphorylationsearch positive regulation of cell proliferationsearch G2/M transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cell divisionsearch G1/S transition of mitotic cell cyclesearch blood coagulationsearch positive regulation of transcription, DNA-templatedsearch centrosome duplicationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch mitotic cell cyclesearch cell cyclesearch mitotic G1 DNA damage checkpointsearch cellular response to nitric oxidesearch meiotic nuclear divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of gene silencingsearch Ras protein signal transductionsearch DNA replicationsearch potassium ion transportsearch cellular response to DNA damage stimulussearch cytosolsearch nucleussearch cytoskeletonsearch nucleoplasmsearch X chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch cytoplasmsearch Cajal bodysearch condensed chromosomesearch endosomesearch centrosomesearch microtubule organizing centersearch transcription factor complexsearch chromosome, telomeric regionsearch Y chromosomesearch
B, D (P20248) protein kinase bindingsearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch