2iv8 Summary



The structure was published by Schmid, E.M., Ford, M.G.J., Burtey, A., et al., Mills, I.G., Benmerah, A., and Mcmahon, H.T., in 2006 in a paper entitled "Role of the Ap2 Beta-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely AP-2 COMPLEX SUBUNIT BETA-1 and BETA-ARRESTIN-1.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AP-2 COMPLEX SUBUNIT BETA-1 P63010 (700-937) (AP2B1_HUMAN)search Homo sapienssearch < 90% 238 97%
P BETA-ARRESTIN-1 P49407 (383-402) (ARRB1_HUMAN)search Homo sapienssearch < 90% 20 70%
Q BETA-ARRESTIN-1 P49407 (383-402) (ARRB1_HUMAN)search Homo sapienssearch < 90% 20 70%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P63010 (700 - 937) AP-2 COMPLEX SUBUNIT BETA-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Alpha-adaptin ear subdomain-likesearch, Clathrin adaptor appendage, alpha and beta chain-specific domainsearch Immunoglobulin-likesearch, TATA-Binding Proteinsearch Adaptin C-terminal domainsearch, Beta2-adaptin appendage, C-terminal sub-domainsearch
P, Q

Chain ID Biological process (GO) Cellular component (GO)
A (P63010) vesicle-mediated transportsearch intracellular protein transportsearch clathrin adaptor complexsearch membrane coatsearch

Chain InterPro annotation
A Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomainsearch Coatomer/calthrin adaptor appendage, C-terminal subdomainsearch Beta2-adaptin/TBP, C-terminal domainsearch Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomainsearch Coatomer/clathrin adaptor appendage, Ig-like subdomainsearch Beta-adaptin appendage, C-terminal subdomainsearch AP complex subunit betasearch
P, Q