2itp Summary

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CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN G719S MUTATION IN COMPLEX WITH AEE788

The structure was published by Yun, C.-H., Boggon, T.J., Li, Y., et al., Greulich, H., Meyerson, M., and Eck, M.J., in 2007 in a paper entitled "Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.74 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR. This molecule has the UniProt identifier P00533 (EGFR_HUMAN)search. The sample contained 327 residues which is < 90% of the natural sequence. Out of 327 residues 305 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR P00533 (696-1022) (EGFR_HUMAN)search Homo sapienssearch < 90% 327 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00533 (696 - 1022) EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P00533) transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein kinase activitysearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Tyrosine-protein kinase, catalytic domainsearch