2isd Summary


PDB entry 2isd (supersedes 1isd)


The structure was published by Essen, L.O., Perisic, O., Cheung, R., Katan, M., and Williams, R.L., in 1996 in a paper entitled "Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ISOZYME DELTA1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ISOZYME DELTA1 P10688 (133-756) (PLCD1_RAT)search Rattus norvegicussearch < 90% 624 89%
B PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ISOZYME DELTA1 P10688 (133-756) (PLCD1_RAT)search Rattus norvegicussearch < 90% 624 89%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B EF-hand modules in multidomain proteinssearch, PLC-like (P variant)search, Mammalian PLCsearch EF-handsearch, Phosphatidylinositol (PI) phosphodiesterasesearch, C2- domain Calcium/lipid binding domainsearch C2 domainsearch, Phosphatidylinositol-specific phospholipase C, Y domainsearch, Phosphatidylinositol-specific phospholipase C, X domainsearch, Phosphoinositide-specific phospholipase C, efhand-likesearch, EF handsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P10688) calcium ion bindingsearch phosphoric diester hydrolase activitysearch phosphatidylinositol phospholipase C activitysearch intracellular signal transductionsearch lipid metabolic processsearch signal transductionsearch

Chain InterPro annotation
A, B C2 domainsearch Phospholipase C, phosphatidylinositol-specific , X domainsearch Phosphoinositide phospholipase C familysearch Phospholipase C, phosphatidylinositol-specific, Y domainsearch EF-hand domainsearch EF-hand domain pairsearch Phospholipase C, phosphoinositol-specific, EF-hand-likesearch PLC-like phosphodiesterase, TIM beta/alpha-barrel domainsearch EF-Hand 1, calcium-binding sitesearch 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1search