2ipp Summary


Crystal Structure of the tetragonal form of human liver cathepsin B

A publication describing this structure is not available. The depositing authors are Huber, C.P.search; Campbell, R.L.search; Hasnain, S.search; Hirama, T.search; To, R.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cathepsin B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cathepsin B P07858 (80-126) (CATB_HUMAN)search Homo sapienssearch < 90% 47 100%
B Cathepsin B P07858 (129-333) (CATB_HUMAN)search Homo sapienssearch < 90% 205 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07858 (80 - 126) Cathepsin B Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch Papain family cysteine proteasesearch
B Cysteine proteinasessearch Papain family cysteine proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P07858) cysteine-type peptidase activitysearch proteolysissearch
B (P07858) cysteine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch
B Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch