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Crystal Structure of the tetragonal form of human liver cathepsin B

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.22.1: Cathepsin B

Reaction catalysed:
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
Alternative Name(s):
  • Cathepsin B1
  • Cathepsin II

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Cathepsin B heavy chain
The deposited structure of PDB entry 2ipp contains 1 copy of Pfam domain PF00112 (Papain family cysteine protease) in Cathepsin B heavy chain. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Cathepsin B light chain
  2. Cathepsin B heavy chain
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Cathepsin B light chain
  2. Cathepsin B heavy chain
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Cathepsin B heavy chain
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Cathepsin B heavy chain
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Cathepsin B heavy chain
IPR000169
Domain description: Cysteine peptidase, cysteine active site
Occurring in:
  1. Cathepsin B light chain

Structure domains

CATH CATH domains
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Cathepsin B heavy chain
The deposited structure of PDB entry 2ipp contains 1 copy of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Cathepsin B heavy chain. Showing 1 copy in chain B.
1.20.5.170
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Cathepsin B light chain
The deposited structure of PDB entry 2ipp contains 1 copy of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Cathepsin B light chain. Showing 1 copy in chain A.

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