2ipk Summary details

spacer Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2
Header IMMUNE SYSTEMsearch
Experiment Resolution: 2.3 Å, R-factor: 22.5%, Free R-factor: 22.4%, Spacegroup: H 3
Released 13/03/2007, deposition: 12/10/2006, last revision: 24/02/2009
Authors Nguyen, T.T.search; Stern, L.J.search
Primary citation Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.
NAT.CHEM.BIOL.search vol:3, pag:222-228 (2007) [PubMed 17351628 ]search
Keywords HLAsearch, DR1search, MHCsearch, Major Histocompatibility Complexsearch, Fluorogenic Probesearch, SEC3search, 4-(Nsearch, N-dimethylamino)phthalimidoalanylsearch, DAPAsearch, IMMUNE SYSTEMsearch
Organism Homo sapiens(human) 9606search(A B),Staphylococcus aureus subsp. aureus Mu50 158878search(D)
UniProt P01903search (A)
P04229search (B)
A8CDU0search (C)
P0A0L5search (D)
Solvent A, B, C, D
Related entries 1jwu, 1dlh
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A HLA class II histocompatibility antigen, DR alpha chain Protein P01903 (DRA_HUMAN)search
183 97%
B HLA class II histocompatibility antigen, DRB1-1 beta chain Protein P04229 (2B11_HUMAN)search
190 100%
C HA related Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) Protein A8CDU0 (A8CDU0_9INFA)search
14 100%
D Enterotoxin type C-3 Protein P0A0L5 (ENTC3_STAAU)search
240 96%