spacer Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2
CATH: Protein Structure Classification
CATH code 3.10.320.10 search
Domains
2ipkA01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: extracellular domain, residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: extracellular domain, residues 30-219. Synonym: mhc class i antigen drb1*1, dr-1, dr1. Engineered: yes. Ha related fluorogenic peptide, acpkxvkqntlklat (x=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2h-isoindol- 2-yl]-l-alanine). Chain: c. Engineered: yes. Enterotoxin type c-3. Chain: d. Fragment: residues 28-266. Synonym: sec3. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Polymers A
Hierarchy
Class Alpha Betasearch
Architecture Roll search
Topology Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
Homologous superfamily Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
 
CATH code 2.60.40.10 search
Domains
2ipkA02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: extracellular domain, residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: extracellular domain, residues 30-219. Synonym: mhc class i antigen drb1*1, dr-1, dr1. Engineered: yes. Ha related fluorogenic peptide, acpkxvkqntlklat (x=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2h-isoindol- 2-yl]-l-alanine). Chain: c. Engineered: yes. Enterotoxin type c-3. Chain: d. Fragment: residues 28-266. Synonym: sec3. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Polymers A
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 3.10.320.10 search
Domains
2ipkB01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: extracellular domain, residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: extracellular domain, residues 30-219. Synonym: mhc class i antigen drb1*1, dr-1, dr1. Engineered: yes. Ha related fluorogenic peptide, acpkxvkqntlklat (x=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2h-isoindol- 2-yl]-l-alanine). Chain: c. Engineered: yes. Enterotoxin type c-3. Chain: d. Fragment: residues 28-266. Synonym: sec3. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Polymers B
Hierarchy
Class Alpha Betasearch
Architecture Roll search
Topology Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
Homologous superfamily Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
 
CATH code 2.60.40.10 search
Domains
2ipkB02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: extracellular domain, residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: extracellular domain, residues 30-219. Synonym: mhc class i antigen drb1*1, dr-1, dr1. Engineered: yes. Ha related fluorogenic peptide, acpkxvkqntlklat (x=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2h-isoindol- 2-yl]-l-alanine). Chain: c. Engineered: yes. Enterotoxin type c-3. Chain: d. Fragment: residues 28-266. Synonym: sec3. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Polymers B
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 3.10.20.120 search
Domains
2ipkD01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: extracellular domain, residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: extracellular domain, residues 30-219. Synonym: mhc class i antigen drb1*1, dr-1, dr1. Engineered: yes. Ha related fluorogenic peptide, acpkxvkqntlklat (x=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2h-isoindol- 2-yl]-l-alanine). Chain: c. Engineered: yes. Enterotoxin type c-3. Chain: d. Fragment: residues 28-266. Synonym: sec3. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Polymers D
Uniprot P0A0L5
Hierarchy
Class Alpha Betasearch
Architecture Roll search
Topology Ubiquitin-like (UB roll) search
Homologous superfamily Ubiquitin-like (UB roll) search
 
CATH code 2.40.50.110 search
Domains
2ipkD02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: extracellular domain, residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: extracellular domain, residues 30-219. Synonym: mhc class i antigen drb1*1, dr-1, dr1. Engineered: yes. Ha related fluorogenic peptide, acpkxvkqntlklat (x=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2h-isoindol- 2-yl]-l-alanine). Chain: c. Engineered: yes. Enterotoxin type c-3. Chain: d. Fragment: residues 28-266. Synonym: sec3. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Polymers D
Uniprot P0A0L5
Hierarchy
Class Mainly Betasearch
Architecture Beta Barrel search
Topology OB fold (Dihydrolipoamide Acetyltransferase, E2P) search
Homologous superfamily OB fold (Dihydrolipoamide Acetyltransferase, E2P) search
 
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