› 2iom

X-ray diffraction
2Å resolution

Mouse p53 core domain soaked with 2-propanol

Released:
DOI: 10.2210/pdb2iom/pdb
PDB entry 2iom coloured by chain, front view.
PDB entry 2iom coloured by chain, side view.
PDB entry 2iom coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds.
Ho WC, Luo C, Zhao K, Chai X, Fitzgerald MX, Marmorstein R
Acta Crystallogr D Biol Crystallogr 62 1484-93 (2006)
PMID: 17139084

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135466 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 22.81 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P02340 (Residues: 92-292; Coverage: 52%)
Gene names: P53, Tp53, Trp53
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand TRS 1 x TRS
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 92.299Å b: 44.541Å c: 62.915Å
α: 90° β: 126.23° γ: 90°
R-values:
R R work R free
0.209 0.209 0.246
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Structural biology of the tumor suppressor p53.
Joerger et al. (2008)
3 more

1 mention without citation

Improving protocols for protein mapping through proper comparison to crystallography data.
Lexa et al. (2013)