2iok Summary

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Human estrogen receptor alpha ligand-binding domain in complex with compound 1D

The structure was published by Dykstra, K.D., Guo, L., Birzin, E.T., et al., Rohrer, S.P., Schaeffer, J.M., and Hammond, M.L., in 2007 in a paper entitled "Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Estrogen receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor P03372 (301-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 254 89%
B Estrogen receptor P03372 (301-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 254 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03372 (301 - 554) Estrogen receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Oestrogen-type nuclear receptor final C-terminalsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P03372) nucleussearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch