› › Structure analysis

Crystal structure of the CIA- histone H3-H4 complex

X-ray diffraction
2.7Å resolution
PDB entry 2io5 coloured by chain, front view.
PDB entry 2io5 coloured by chain, side view.
PDB entry 2io5 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero trimer
Accessible surface area: 15702.98 Å2
Buried surface area: 6854.65 Å2
Dissociation area: 1,337.82 Å2
Dissociation energy (ΔGdiss): 3.74 kcal/mol
Dissociation entropy (TΔSdiss): 11.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158669

Macromolecules

Histone chaperone ASF1A
Chain: A
Length: 175 amino acids
Theoretical weight: 19.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y294 (Residues: 1-172; Coverage: 84%)
Gene names: ASF1A, CGI-98, HSPC146
Pfam: ASF1 like histone chaperone
InterPro:
CATH: Histone chaperone ASF1-like
SCOP: ASF1-like
Histone chaperone ASF1A in PDB entry 2io5, assembly 1, front view.
Histone chaperone ASF1A in PDB entry 2io5, assembly 1, side view.
Histone chaperone ASF1A in PDB entry 2io5, assembly 1, top view.
Molecule details ›

Search similar proteins

Histone H3.2
Chain: B
Length: 135 amino acids
Theoretical weight: 15.29 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: P84233 (Residues: 2-136; Coverage: 99%)
Pfam: Core histone H2A/H2B/H3/H4
InterPro:
CATH: Histone, subunit A
Histone H3.2 in PDB entry 2io5, assembly 1, front view.
Histone H3.2 in PDB entry 2io5, assembly 1, side view.
Histone H3.2 in PDB entry 2io5, assembly 1, top view.
Molecule details ›

Search similar proteins

Histone H4
Chain: C
Length: 102 amino acids
Theoretical weight: 11.26 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: P62799 (Residues: 2-103; Coverage: 99%)
Pfam: Centromere kinetochore component CENP-T histone fold
InterPro:
CATH: Histone, subunit A
SCOP: Nucleosome core histones
Histone H4 in PDB entry 2io5, assembly 1, front view.
Histone H4 in PDB entry 2io5, assembly 1, side view.
Histone H4 in PDB entry 2io5, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links