› 2iic

X-ray diffraction
2.93Å resolution

Calcium bound structure of alpha-11 giardin

Released:
DOI: 10.2210/pdb2iic/pdb
PDB entry 2iic coloured by chain, front view.
PDB entry 2iic coloured by chain, side view.
PDB entry 2iic coloured by chain, top view.
Source organism: Giardia intestinalis
Primary publication:
Apo and calcium-bound crystal structures of Alpha-11 giardin, an unusual annexin from Giardia lamblia.
Pathuri P, Nguyen ET, Svärd SG, Luecke H
J Mol Biol 368 493-508 (2007)
PMID: 17355882

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-11 giardin fourth annexin domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 310 amino acids
Theoretical weight: 35.25 KDa
Source organism: Giardia intestinalis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4VPP2 (Residues: 2-307; Coverage: 100%)
Sequence domains: Alpha-11 giardin annexin domain
Structure domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P21
Unit cell:
a: 129.3Å b: 45.285Å c: 131.901Å
α: 90° β: 116.39° γ: 90°
R-values:
R R work R free
0.264 0.264 0.306
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Parasite annexins--new molecules with potential for drug and vaccine development.
Hofmann et al. (2010)
1 more

2 mentions without citation

Apo and calcium-bound crystal structures of Alpha-11 giardin, an unusual annexin from Giardia lamblia.
Pathuri et al. (2007)
1 more