2ig7 Summary


Crystal structure of Human Choline Kinase B

A publication describing this structure is not available. The depositing authors are Rabeh, W.M.search; Tempel, W.search; Nedyalkova, L.search; Wasney, G.search; Landry, R.search; Vedadi, M.search; Arrowsmith, C.H.search; Edwards, A.M.search; Sundstrom, M.search; Weigelt, J.search; Bochkarev, A.search; Park, H.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Choline/ethanolamine kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Choline/ethanolamine kinase Q9Y259 (14-395) (CHKB_HUMAN)search Homo sapienssearch 91% 401 85%
B Choline/ethanolamine kinase Q9Y259 (14-395) (CHKB_HUMAN)search Homo sapienssearch 91% 401 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9Y259 (14 - 395) Choline/ethanolamine kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q9Y259) Choline kinase; domain 1search, Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2search PF01633: Choline/ethanolamine kinasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (Q9Y259) phosphatidylcholine biosynthetic processsearch small molecule metabolic processsearch lipid metabolic processsearch phosphatidylethanolamine biosynthetic processsearch CDP-choline pathwaysearch muscle organ developmentsearch glycerophospholipid biosynthetic processsearch phosphorylationsearch phospholipid metabolic processsearch phospholipid biosynthetic processsearch cytosolsearch kinase activitysearch ethanolamine kinase activitysearch ATP bindingsearch nucleotide bindingsearch choline kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B Protein kinase-like domainsearch