2ig7 Summary


Crystal structure of Human Choline Kinase B

A publication describing this structure is not available. The depositing authors are Rabeh, W.M.search; Tempel, W.search; Nedyalkova, L.search; Wasney, G.search; Landry, R.search; Vedadi, M.search; Arrowsmith, C.H.search; Edwards, A.M.search; Sundstrom, M.search; Weigelt, J.search; Bochkarev, A.search; Park, H.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Choline/ethanolamine kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Choline/ethanolamine kinase Q9Y259 (14-395) (CHKB_HUMAN)search Homo sapienssearch 91% 401 85%
B Choline/ethanolamine kinase Q9Y259 (14-395) (CHKB_HUMAN)search Homo sapienssearch 91% 401 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9Y259 (14 - 395) Choline/ethanolamine kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q9Y259) Choline kinase; domain 1search, Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2search PF01633: Choline/ethanolamine kinasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q9Y259) kinase activitysearch ATP bindingsearch choline kinase activitysearch ethanolamine kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch cytosolsearch phosphorylationsearch phosphatidylethanolamine biosynthetic processsearch small molecule metabolic processsearch lipid metabolic processsearch CDP-choline pathwaysearch glycerophospholipid biosynthetic processsearch phospholipid metabolic processsearch phospholipid biosynthetic processsearch phosphatidylcholine biosynthetic processsearch

Chain InterPro annotation
A, B Protein kinase-like domainsearch