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Crystal structure of Human Choline Kinase B

X-ray diffraction
1.8Å resolution
PDB entry 2ig7 coloured by chain, front view.
PDB entry 2ig7 coloured by chain, side view.
PDB entry 2ig7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Choline/ethanolamine kinase
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Multimeric state: homo dimer
Accessible surface area: 29177.06 Å2
Buried surface area: 2185.86 Å2
Dissociation area: 1,092.93 Å2
Dissociation energy (ΔGdiss): 8.44 kcal/mol
Dissociation entropy (TΔSdiss): 13.91 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-195103

Macromolecules

Choline/ethanolamine kinase
Chains: A, B
Length: 401 amino acids
Theoretical weight: 46.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y259 (Residues: 14-395; Coverage: 97%)
Gene names: CHETK, CHKB, CHKL
Pfam: Choline/ethanolamine kinase
InterPro: Protein kinase-like domain superfamily
CATH:
Choline/ethanolamine kinase in PDB entry 2ig7, assembly 1, front view.
Choline/ethanolamine kinase in PDB entry 2ig7, assembly 1, side view.
Choline/ethanolamine kinase in PDB entry 2ig7, assembly 1, top view.
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