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EBI PDBe PDBeView

PDBe Entry: 2ie4 view

Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid
Summary
Header SIGNALING PROTEIN,HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.6 Å, R-factor: 25.0%, Free R-factor: 23.0%, Spacegroup: I 2 2 2
Released 07/11/2006, deposition: 17/09/2006, last revision: 24/02/2009
Authors Xing, Y.search; Xu, Y.search; Chen, Y.search; Jeffrey, P.D.search; Chao, Y.search; Shi, Y.search
Primary citation Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
CELL(CAMBRIDGE,MASS.)search vol:127, pag:341-353 (2006) [PubMed ID 17055435 ]search
Keywords protein-protein complexsearch, HEAT repeatsearch, SIGNALING PROTEINsearch, HYDROLASEsearch
EC 3.1.3.16 ExPASy BRENDA search (C)
Organism Homo sapiens(human) 9606search(A C)
UniProt Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor antigen-associated 61 kDa protein) P30153search (A)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (EC 3.1.3.16) (PP2A-alpha) (Replication protein C) (RP-C) P67775search (C)
Solvent A, C
Related entries 2ie3
Polymers
Id Name Type UniProt Residues Observed
A Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform Protein P30153 (2AAA_HUMAN)search
 589 98%
C Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Protein P67775 (PP2AA_HUMAN)search
 309 93%
Heterogens
Id Name Ligands
C MANGANESE (II) ION MN search
C OKADAIC ACID OKA search
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