spacer Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule
CATH: Protein Structure Classification
CATH code 3.10.320.10 search
Domains
2icwA01 , 2icwD01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d.Fragment: residues 28-206. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Haemagglutinin peptide. Chain: c, f. Fragment: residues 306-318. Engineered: yes. Mycoplasma arthritidismitogen. Chain: g, h. Fragment: residues 26-238. Engineered: yes. T-cell receptor alpha chain v. Chain: i, k. Fragment: residues 21-131. Engineered: yes. Mutation: yes. T-cell receptor beta chain v. Chain: j, l. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers A, D
Hierarchy
Class Alpha Betasearch
Architecture Roll search
Topology Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
Homologous superfamily Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
 
CATH code 2.60.40.10 search
Domains
2icwA02 , 2icwD02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d.Fragment: residues 28-206. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Haemagglutinin peptide. Chain: c, f. Fragment: residues 306-318. Engineered: yes. Mycoplasma arthritidismitogen. Chain: g, h. Fragment: residues 26-238. Engineered: yes. T-cell receptor alpha chain v. Chain: i, k. Fragment: residues 21-131. Engineered: yes. Mutation: yes. T-cell receptor beta chain v. Chain: j, l. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers A, D
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 3.10.320.10 search
Domains
2icwB01 , 2icwE01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d.Fragment: residues 28-206. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Haemagglutinin peptide. Chain: c, f. Fragment: residues 306-318. Engineered: yes. Mycoplasma arthritidismitogen. Chain: g, h. Fragment: residues 26-238. Engineered: yes. T-cell receptor alpha chain v. Chain: i, k. Fragment: residues 21-131. Engineered: yes. Mutation: yes. T-cell receptor beta chain v. Chain: j, l. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers B, E
Hierarchy
Class Alpha Betasearch
Architecture Roll search
Topology Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
Homologous superfamily Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
 
CATH code 2.60.40.10 search
Domains
2icwB02 , 2icwE02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d.Fragment: residues 28-206. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Haemagglutinin peptide. Chain: c, f. Fragment: residues 306-318. Engineered: yes. Mycoplasma arthritidismitogen. Chain: g, h. Fragment: residues 26-238. Engineered: yes. T-cell receptor alpha chain v. Chain: i, k. Fragment: residues 21-131. Engineered: yes. Mutation: yes. T-cell receptor beta chain v. Chain: j, l. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers B, E
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 1.20.120.390 search
Domains
2icwG01 , 2icwH01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d.Fragment: residues 28-206. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Haemagglutinin peptide. Chain: c, f. Fragment: residues 306-318. Engineered: yes. Mycoplasma arthritidismitogen. Chain: g, h. Fragment: residues 26-238. Engineered: yes. T-cell receptor alpha chain v. Chain: i, k. Fragment: residues 21-131. Engineered: yes. Mutation: yes. T-cell receptor beta chain v. Chain: j, l. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers G, H
Hierarchy
Class Mainly Alphasearch
Architecture Up-down Bundle search
Topology Four Helix Bundle (Hemerythrin (Met), subunit A) search
Homologous superfamily Hla class ii histocompatibility antigen, dr alpha chain. Chain D, domain 1 search
 
CATH code 1.10.10.530 search
Domains
2icwG02 , 2icwH02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d.Fragment: residues 28-206. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Haemagglutinin peptide. Chain: c, f. Fragment: residues 306-318. Engineered: yes. Mycoplasma arthritidismitogen. Chain: g, h. Fragment: residues 26-238. Engineered: yes. T-cell receptor alpha chain v. Chain: i, k. Fragment: residues 21-131. Engineered: yes. Mutation: yes. T-cell receptor beta chain v. Chain: j, l. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers G, H
Hierarchy
Class Mainly Alphasearch
Architecture Orthogonal Bundle search
Topology Arc Repressor Mutant, subunit A search
Homologous superfamily mam-mhc complex, Chain D, Domain 2 search
 
CATH code 2.60.40.10 search
Domains
2icwI00 , 2icwK00
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d.Fragment: residues 28-206. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Haemagglutinin peptide. Chain: c, f. Fragment: residues 306-318. Engineered: yes. Mycoplasma arthritidismitogen. Chain: g, h. Fragment: residues 26-238. Engineered: yes. T-cell receptor alpha chain v. Chain: i, k. Fragment: residues 21-131. Engineered: yes. Mutation: yes. T-cell receptor beta chain v. Chain: j, l. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers I, K
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 2.60.40.10 search
Domains
2icwJ00 , 2icwL00
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d.Fragment: residues 28-206. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Haemagglutinin peptide. Chain: c, f. Fragment: residues 306-318. Engineered: yes. Mycoplasma arthritidismitogen. Chain: g, h. Fragment: residues 26-238. Engineered: yes. T-cell receptor alpha chain v. Chain: i, k. Fragment: residues 21-131. Engineered: yes. Mutation: yes. T-cell receptor beta chain v. Chain: j, l. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers J, L
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
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