2iam Summary

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Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR

The structure was published by Deng, L., Langley, R.J., Brown, P.H., et al., Nishimura, M.I., Topalian, S.L., and Mariuzza, R.A., in 2007 in a paper entitled "Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This entry contains 10 copies of 5 unique biopolymers (complete list).

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA class II histocompatibility antigen, DR alpha chain P01903 (26-207) (DRA_HUMAN)search Homo sapienssearch < 90% 182 98%
B HLA class II histocompatibility antigen, DRB1-1 beta chain P04229 (30-219) (2B11_HUMAN)search Homo sapienssearch < 90% 190 95%
P 15-mer peptide from Triosephosphate isomerase P60174 (60-74) (TPIS_HUMAN)search Homo sapienssearch < 90% 15 100%
C CD4+ T cell receptor E8 alpha chain P01848 (1-95) (TCA_HUMAN)search Homo sapienssearch < 90% 202 98%
D CD4+ T cell receptor E8 beta chain Not available
Homo sapienssearch Not available 240 99%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 207) HLA class II histocompatibility antigen, DR alpha chain Homo sapiens
P04229 (30 - 219) HLA class II histocompatibility antigen, DRB1-1 beta chain Homo sapiens
P60174 (60 - 74) 15-mer peptide from Triosephosphate isomerase Homo sapiens
P01848 (1 - 95) CD4+ T cell receptor E8 alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
P Triosephosphate isomerasesearch
C Immunoglobulinssearch Domain of unknown function (DUF1968)search
D Immunoglobulinssearch Immunoglobulin C1-set domainsearch

Chain ID Biological process (GO) Cellular component (GO)
A (P01903) antigen processing and presentationsearch immune responsesearch membranesearch MHC class II protein complexsearch
B (P04229) immune responsesearch antigen processing and presentationsearch MHC class II protein complexsearch membranesearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
P
C Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch Domain of unknown function DUF1968search
D Immunoglobulin C1-setsearch Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch