spacer Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
CATH: Protein Structure Classification
CATH code 3.10.320.10 search
Domains
2iamA01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: residues 1-182 (26-207). Synonym: mhc class ii antigen dra, major histocompatibility complex class ii hla-dr1 alpha chain. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: residues 1-190 (30-219). Synonym: mhc class i antigendrb1*1, dr-1, dr1, major histocompatibility complex class ii hla-dr1beta chain. Engineered: yes. 15-mer peptide from triosephosphate isomerase. Chain: p. Fragment: residues 23-37 (22-36). Engineered: yes. Mutation: yes. Cd4+ t cell receptor e8 alpha chain. Chain: c. Engineered:yes. Mutation: yes. Cd4+ t cell receptor e8 beta chain. Chain: d. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Polymers A
Hierarchy
Class Alpha Betasearch
Architecture Roll search
Topology Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
Homologous superfamily Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
 
CATH code 2.60.40.10 search
Domains
2iamA02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: residues 1-182 (26-207). Synonym: mhc class ii antigen dra, major histocompatibility complex class ii hla-dr1 alpha chain. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: residues 1-190 (30-219). Synonym: mhc class i antigendrb1*1, dr-1, dr1, major histocompatibility complex class ii hla-dr1beta chain. Engineered: yes. 15-mer peptide from triosephosphate isomerase. Chain: p. Fragment: residues 23-37 (22-36). Engineered: yes. Mutation: yes. Cd4+ t cell receptor e8 alpha chain. Chain: c. Engineered:yes. Mutation: yes. Cd4+ t cell receptor e8 beta chain. Chain: d. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Polymers A
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 3.10.320.10 search
Domains
2iamB01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: residues 1-182 (26-207). Synonym: mhc class ii antigen dra, major histocompatibility complex class ii hla-dr1 alpha chain. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: residues 1-190 (30-219). Synonym: mhc class i antigendrb1*1, dr-1, dr1, major histocompatibility complex class ii hla-dr1beta chain. Engineered: yes. 15-mer peptide from triosephosphate isomerase. Chain: p. Fragment: residues 23-37 (22-36). Engineered: yes. Mutation: yes. Cd4+ t cell receptor e8 alpha chain. Chain: c. Engineered:yes. Mutation: yes. Cd4+ t cell receptor e8 beta chain. Chain: d. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Polymers B
Hierarchy
Class Alpha Betasearch
Architecture Roll search
Topology Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
Homologous superfamily Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
 
CATH code 2.60.40.10 search
Domains
2iamB02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: residues 1-182 (26-207). Synonym: mhc class ii antigen dra, major histocompatibility complex class ii hla-dr1 alpha chain. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: residues 1-190 (30-219). Synonym: mhc class i antigendrb1*1, dr-1, dr1, major histocompatibility complex class ii hla-dr1beta chain. Engineered: yes. 15-mer peptide from triosephosphate isomerase. Chain: p. Fragment: residues 23-37 (22-36). Engineered: yes. Mutation: yes. Cd4+ t cell receptor e8 alpha chain. Chain: c. Engineered:yes. Mutation: yes. Cd4+ t cell receptor e8 beta chain. Chain: d. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Polymers B
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 2.60.40.10 search
Domains
2iamC01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: residues 1-182 (26-207). Synonym: mhc class ii antigen dra, major histocompatibility complex class ii hla-dr1 alpha chain. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: residues 1-190 (30-219). Synonym: mhc class i antigendrb1*1, dr-1, dr1, major histocompatibility complex class ii hla-dr1beta chain. Engineered: yes. 15-mer peptide from triosephosphate isomerase. Chain: p. Fragment: residues 23-37 (22-36). Engineered: yes. Mutation: yes. Cd4+ t cell receptor e8 alpha chain. Chain: c. Engineered:yes. Mutation: yes. Cd4+ t cell receptor e8 beta chain. Chain: d. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Polymers C
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 2.60.40.10 search
Domains
2iamD01 , 2iamD02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a. Fragment: residues 1-182 (26-207). Synonym: mhc class ii antigen dra, major histocompatibility complex class ii hla-dr1 alpha chain. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b. Fragment: residues 1-190 (30-219). Synonym: mhc class i antigendrb1*1, dr-1, dr1, major histocompatibility complex class ii hla-dr1beta chain. Engineered: yes. 15-mer peptide from triosephosphate isomerase. Chain: p. Fragment: residues 23-37 (22-36). Engineered: yes. Mutation: yes. Cd4+ t cell receptor e8 alpha chain. Chain: c. Engineered:yes. Mutation: yes. Cd4+ t cell receptor e8 beta chain. Chain: d. Engineered: yes. Mutation: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Polymers D
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
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