2i4z Summary


Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). This structure has been obtained from crystals soaked for 6 hours.

The structure was published by Pochetti, G., Godio, C., Mitro, N., et al., Novellino, E., Mazza, F., and Crestani, M., in 2007 in a paper entitled "Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Peroxisome proliferator-activated receptor gamma.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator-activated receptor gamma P37231 (223-504) (PPARG_HUMAN)search Homo sapienssearch < 90% 286 94%
B Peroxisome proliferator-activated receptor gamma P37231 (223-504) (PPARG_HUMAN)search Homo sapienssearch < 90% 286 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37231 (223 - 504) Peroxisome proliferator-activated receptor gamma Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P37231) nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch