2i4h Summary


Structural studies of protein tyrosine phosphatase beta catalytic domain co-crystallized with a sulfamic acid inhibitor

The structure was published by Evdokimov, A.G., Pokross, M., Walter, R., et al., Gray, J., Maier, M., and Peters, K.G., in 2006 in a paper entitled "Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Receptor-type tyrosine-protein phosphatase beta. This molecule has the UniProt identifier P23467 (PTPRB_HUMAN)search. The sample contained 313 residues which is < 90% of the natural sequence. Out of 313 residues 279 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Receptor-type tyrosine-protein phosphatase beta P23467 (1662-1973) (PTPRB_HUMAN)search Homo sapienssearch < 90% 313 89%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23467 (1662 - 1973) Receptor-type tyrosine-protein phosphatase beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Protein tyrosine phosphatase superfamilysearch Protein-tyrosine phosphatasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P23467) phosphatase activitysearch protein tyrosine phosphatase activitysearch dephosphorylationsearch protein dephosphorylationsearch

Chain InterPro annotation
A Protein-tyrosine phosphatase, receptor/non-receptor typesearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch Protein-tyrosine phosphatase-likesearch