› 2i3w

X-ray diffraction
2.3Å resolution

Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant

Released:
DOI: 10.2210/pdb2i3w/pdb
PDB entry 2i3w coloured by chain, front view.
PDB entry 2i3w coloured by chain, side view.
PDB entry 2i3w coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor.
Armstrong N, Jasti J, Beich-Frandsen M, Gouaux E
Cell 127 85-97 (2006)
PMID: 17018279

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 259 amino acids
Theoretical weight: 28.97 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-794; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand GLU 2 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 47.002Å b: 93.142Å c: 138.244Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.24 0.284
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
23 more

8 mentions without citation

Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
Dürr et al. (2014)
7 more