2i1m Summary

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cFMS tyrosine kinase (tie2 KID) in complex with an arylamide inhibitor

The structure was published by Schubert, C., Schalk-Hihi, C., Struble, G.T., et al., Player, M.R., Spurlino, J.C., and Springer, B.A., in 2007 in a paper entitled "Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Macrophage colony-stimulating factor 1 receptor. This molecule has the UniProt identifier P07333 (CSF1R_HUMAN)search. The sample contained 333 residues which is < 90% of the natural sequence. Out of 333 residues 311 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Macrophage colony-stimulating factor 1 receptor P07333 (538-678) (CSF1R_HUMAN)search ,
P07333 (753-922) (CSF1R_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
333 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07333 (538 - 678) Macrophage colony-stimulating factor 1 receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P07333) membranesearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch