› 2i1m

X-ray diffraction
1.8Å resolution

cFMS tyrosine kinase (tie2 KID) in complex with an arylamide inhibitor

Released:
DOI: 10.2210/pdb2i1m/pdb
PDB entry 2i1m coloured by chain, front view.
PDB entry 2i1m coloured by chain, side view.
PDB entry 2i1m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.
Schubert C, Schalk-Hihi C, Struble GT, Ma HC, Petrounia IP, Brandt B, Deckman IC, Patch RJ, Player MR, Spurlino JC, Springer BA
J Biol Chem 282 4094-101 (2007)
PMID: 17132624

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139513 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 333 amino acids
Theoretical weight: 37.61 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07333 (Residues: 538-922; Coverage: 35%)
Gene names: CSF1R, FMS
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 5CN 1 x 5CN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: R3
Unit cell:
a: 80.44Å b: 80.44Å c: 143.76Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.237 0.282
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

CSF-1 receptor signaling in myeloid cells.
Stanley et al. (2014)
6 more

6 mentions without citation

A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Chen et al. (2007)
5 more