2i13 Summary


Aart, a six finger zinc finger designed to recognize ANN triplets

The structure was published by Segal, D.J., Crotty, J.W., Bhakta, M.S., Barbas, C.F., and Horton, N.C., in 2006 in a paper entitled "Structure of Aart, a Designed Six-finger Zinc Finger Peptide, Bound to DNA." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.96 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 5'-D(*CP*AP*GP*AP*TP*GP*TP*AP*GP*GP*GP*AP*AP*AP*AP*GP*CP*CP*CP*GP*GP*G)-3', 5'-D(*GP*CP*CP*CP*GP*GP*GP*CP*TP*TP*TP*TP*CP*CP*CP*TP*AP*CP*AP*TP*CP*T)-3', and Aart.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Aart Q07230 (218-372) (ZSCA2_MOUSE)search Mus musculussearch < 90% 190 79%
B Aart Q07230 (218-388) (ZSCA2_MOUSE)search Mus musculussearch < 90% 190 79%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q07230 (218 - 372) Aart Mus musculus

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B Zinc finger designsearch Zinc finger, C2H2 typesearch, Zinc-finger double domainsearch

Chain ID Molecular function (GO)
A, B (Q07230) metal ion bindingsearch nucleic acid bindingsearch

Chain InterPro annotation
A, B Zinc finger, C2H2search Zinc finger C2H2-type/integrase DNA-binding domainsearch Zinc finger, C2H2-likesearch