2i0j Summary


Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia

The structure was published by Norman, B.H., Dodge, J.A., Richardson, T.I., et al., Guo, S., Boodhoo, A., and Krishnan, V., in 2006 in a paper entitled "Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Estrogen receptor alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor alpha P03372 (304-547) (ESR1_HUMAN)search Homo sapienssearch < 90% 244 93%
B Estrogen receptor alpha P03372 (304-547) (ESR1_HUMAN)search Homo sapienssearch < 90% 244 93%
C Estrogen receptor alpha P03372 (304-547) (ESR1_HUMAN)search Homo sapienssearch < 90% 244 93%
D Estrogen receptor alpha P03372 (304-547) (ESR1_HUMAN)search Homo sapienssearch < 90% 244 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03372 (304 - 547) Estrogen receptor alpha Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (P03372) DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B, C, D Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch