2i0g Summary


Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia

The structure was published by Norman, B.H., Dodge, J.A., Richardson, T.I., et al., Guo, S., Boodhoo, A., and Krishnan, V., in 2006 in a paper entitled "Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Estrogen receptor beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor beta Q92731 (256-505) (ESR2_HUMAN)search Homo sapienssearch < 90% 257 86%
B Estrogen receptor beta Q92731 (256-505) (ESR2_HUMAN)search Homo sapienssearch < 90% 257 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q92731 (256 - 505) Estrogen receptor beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q92731) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch thyroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch