2i0e Summary

pdbe.org/2i0e
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Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

The structure was published by Grodsky, N., Li, Y., Bouzida, D., et al., Nodes, B., Nonomiya, J., and Grant, S., in 2006 in a paper entitled "Structure of the Catalytic Domain of Human Protein Kinase C beta II Complexed with a Bisindolylmaleimide Inhibitor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Protein Kinase C-beta II.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein Kinase C-beta II P05771 (321-638) (KPCB_HUMAN)search ,
P05771 (639-645) (KPCB_HUMAN)search ,
P05771 (646-671) (KPCB_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90% ,
< 90%
353 93%
B Protein Kinase C-beta II P05771 (321-638) (KPCB_HUMAN)search ,
P05771 (639-645) (KPCB_HUMAN)search ,
P05771 (646-671) (KPCB_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90% ,
< 90%
353 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05771 (321 - 638) Protein Kinase C-beta II Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P05771) protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch