2hzn Summary

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Abl kinase domain in complex with NVP-AFG210

The structure was published by Cowan-Jacob, S.W., Fendrich, G., Floersheimer, A., et al., Centeleghe, M., Fabbro, D., and Manley, P.W., in 2007 in a paper entitled "Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase ABL1. This molecule has the UniProt identifier P00520 (ABL1_MOUSE)search. The sample contained 293 residues which is < 90% of the natural sequence. Out of 293 residues 269 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase ABL1 P00520 (229-515) (ABL1_MOUSE)search Mus musculussearch < 90% 293 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00520 (229 - 515) Proto-oncogene tyrosine-protein kinase ABL1 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P00520) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch