› 2hyd

X-ray diffraction
3Å resolution

Multidrug ABC transporter SAV1866

Released:
DOI: 10.2210/pdb2hyd/pdb
PDB entry 2hyd coloured by chain, front view.
PDB entry 2hyd coloured by chain, side view.
PDB entry 2hyd coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
Structure of a bacterial multidrug ABC transporter.
Dawson RJ, Locher KP
Nature 443 180-5 (2006)
PMID: 16943773

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative multidrug export ATP-binding/permease protein SAV1866 Chains: A, B
Molecule details ›
Chains: A, B
Length: 578 amino acids
Theoretical weight: 64.93 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99T13 (Residues: 1-578; Coverage: 100%)
Gene name: SAV1866
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NA 2 x NA
Ligand ADP 2 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 161.279Å b: 103.955Å c: 181.013Å
α: 90° β: 97.99° γ: 90°
R-values:
R R work R free
0.264 0.255 0.272
Expression system: Escherichia coli

Quick links

Citations

183 review citations

Lipid A modification systems in gram-negative bacteria.
Raetz et al. (2007)
182 more

129 mentions without citation

ABC transporters: the power to change.
Rees et al. (2009)
128 more