2hwo Summary details

pdbe.org/2hwo/summary_details
spacer Crystal structure of Src kinase domain in complex with covalent inhibitor
Summary
Header transferasesearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.5 Å, R-factor: 23.8%, Free R-factor: 29.2%, Spacegroup: P 1
Released 27/02/2007, deposition: 01/08/2006, last revision: 13/07/2011
Authors Rauh, D.search; Blair, J.A.search; Shokat, K.M.search
Primary citation Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
NAT.CHEM.BIOL.search vol:3, pag:229-238 (2007) [PubMed 17334377 ]search
Keywords kinasesearch, covalentsearch, quinazolinesearch, modificationsearch, transferasesearch
EC 2.7.10.2 ExPASy BRENDA search (A B)
Organism Gallus gallus(chicken) 9031search(A B)
UniProt P00523search (A B)
Solvent A, B
Related entries 2hwp
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, B Proto-oncogene tyrosine-protein kinase Src Protein P00523 (SRC_CHICK)search
286 87%
Heterogens
Chain Id Name Ligands
A, B N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE RBS search
B GLYCEROL GOL search
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