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Crystal Structure of Mnk2-D228G in complex with Staurosporine

X-ray diffraction
2.71Å resolution
PDB entry 2hw7 coloured by chain, front view.
PDB entry 2hw7 coloured by chain, side view.
PDB entry 2hw7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: MAP kinase-interacting serine/threonine-protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 15832.52 Å2
Buried surface area: 999.12 Å2
Dissociation area: 449.46 Å2
Dissociation energy (ΔGdiss): -3.07 kcal/mol
Dissociation entropy (TΔSdiss): 4.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190755

Macromolecules

MAP kinase-interacting serine/threonine-protein kinase 2
Chain: A
Length: 316 amino acids
Theoretical weight: 35.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9HBH9 (Residues: 72-385; Coverage: 68%)
Gene names: GPRK7, MKNK2, MNK2
Pfam: Protein kinase domain
InterPro:
CATH:
MAP kinase-interacting serine/threonine-protein kinase 2 in PDB entry 2hw7, assembly 1, front view.
MAP kinase-interacting serine/threonine-protein kinase 2 in PDB entry 2hw7, assembly 1, side view.
MAP kinase-interacting serine/threonine-protein kinase 2 in PDB entry 2hw7, assembly 1, top view.
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