› 2hw6

X-ray diffraction
2.5Å resolution

Crystal structure of Mnk1 catalytic domain

Released:
DOI: 10.2210/pdb2hw6/pdb
PDB entry 2hw6 coloured by chain, front view.
PDB entry 2hw6 coloured by chain, side view.
PDB entry 2hw6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment.
Jauch R, Cho MK, Jäkel S, Netter C, Schreiter K, Aicher B, Zweckstetter M, Jäckle H, Wahl MC
EMBO J 25 4020-32 (2006)
PMID: 16917500

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189731 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-interacting serine/threonine-protein kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 307 amino acids
Theoretical weight: 34.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BUB5 (Residues: 37-382; Coverage: 66%)
Gene names: MKNK1, MNK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 93.468Å b: 93.468Å c: 175.181Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.257
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1).
Mills et al. (2008)
7 more

12 mentions without citation

Targeting Mnks for cancer therapy.
Hou et al. (2012)
11 more