2hv7 Summary

pdbe.org/2hv7
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Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS

The structure was published by Chao, Y., Xing, Y., Chen, Y., et al., Jeffrey, P.D., Stock, J.B., and Shi, Y., in 2006 in a paper entitled "Structure and mechanism of the phosphotyrosyl phosphatase activator." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Protein phosphatase 2A, regulatory subunit B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%
B Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%
C Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%
D Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%
E Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%
F Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%
G Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%
H Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q15257 (1 - 358) Protein phosphatase 2A, regulatory subunit B Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D, E, F, G, H (Q15257) PTPA-likesearch PF03095: Phosphotyrosyl phosphate activator (PTPA) proteinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D, E, F, G, H (Q15257) protein foldingsearch regulation of phosphoprotein phosphatase activitysearch positive regulation of apoptotic processsearch protein peptidyl-prolyl isomerizationsearch positive regulation of phosphoprotein phosphatase activitysearch ATP catabolic processsearch mitotic spindle organization in nucleussearch positive regulation of protein dephosphorylationsearch negative regulation of phosphoprotein phosphatase activitysearch negative regulation of protein dephosphorylationsearch phosphatase activator activitysearch protein phosphatase type 2A regulator activitysearch peptidyl-prolyl cis-trans isomerase activitysearch protein tyrosine phosphatase activator activitysearch protein homodimerization activitysearch ATP bindingsearch ATPase activitysearch protein phosphatase 2A bindingsearch receptor bindingsearch nucleotide bindingsearch isomerase activitysearch protein heterodimerization activitysearch nucleussearch cytoplasmsearch protein phosphatase type 2A complexsearch nucleolussearch calcium channel complexsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H Phosphotyrosyl phosphatase activator, PTPAsearch