2hv6 Summary

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Crystal structure of the phosphotyrosyl phosphatase activator

The structure was published by Chao, Y., Xing, Y., Chen, Y., et al., Jeffrey, P.D., Stock, J.B., and Shi, Y., in 2006 in a paper entitled "Structure and mechanism of the phosphotyrosyl phosphatase activator." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Protein phosphatase 2A, regulatory subunit B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%
B Protein phosphatase 2A, regulatory subunit B Q15257 (1-358) (PTPA_HUMAN)search Homo sapienssearch 90% 323 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q15257 (1 - 358) Protein phosphatase 2A, regulatory subunit B Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B (Q15257) PTPA-likesearch PF03095: Phosphotyrosyl phosphate activator (PTPA) proteinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q15257) positive regulation of protein dephosphorylationsearch protein peptidyl-prolyl isomerizationsearch positive regulation of apoptotic processsearch mitotic spindle organization in nucleussearch negative regulation of phosphoprotein phosphatase activitysearch regulation of phosphoprotein phosphatase activitysearch positive regulation of phosphoprotein phosphatase activitysearch metabolic processsearch negative regulation of protein dephosphorylationsearch ATP catabolic processsearch protein homodimerization activitysearch receptor bindingsearch protein tyrosine phosphatase activator activitysearch peptidyl-prolyl cis-trans isomerase activitysearch protein phosphatase 2A bindingsearch ATP bindingsearch isomerase activitysearch protein phosphatase type 2A regulator activitysearch phosphatase activator activitysearch ATPase activitysearch protein heterodimerization activitysearch nucleotide bindingsearch cytoplasmsearch protein phosphatase type 2A complexsearch extracellular vesicular exosomesearch nucleoplasmsearch nucleussearch calcium channel complexsearch

Chain InterPro annotation
A, B Phosphotyrosyl phosphatase activator, PTPAsearch