2huw Summary


X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand

The structure was published by Benfield, A.P., Teresk, M.G., Plake, H.R., Delorbe, J.E., Millspaugh, L.E., and Martin, S.F., in 2006 in a paper entitled "Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Growth factor receptor-bound protein 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Growth factor receptor-bound protein 2 P62993 (53-162) (GRB2_HUMAN)search Homo sapienssearch 100% 116 87%
B Growth factor receptor-bound protein 2 P62993 (53-162) (GRB2_HUMAN)search Homo sapienssearch 100% 116 87%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62993 (53 - 162) Growth factor receptor-bound protein 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P62993) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch, PF00018: SH3 domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P62993) SH3/SH2 adaptor activitysearch membranesearch Ras protein signal transductionsearch

Chain InterPro annotation
A, B SH2 domainsearch Growth factor receptor-bound protein 2search