2htr Summary

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N8 neuraminidase in complex with DANA

The structure was published by Russell, R.J., Haire, L.F., Stevens, D.J., et al., Hay, A.J., Gamblin, S.J., and Skehel, J.J., in 2006 in a paper entitled "The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Neuraminidase. This molecule has the UniProt identifier Q07599 (NRAM_I63A3)search. The sample contained 390 residues which is < 90% of the natural sequence. Out of 390 residues 387 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Neuraminidase Q07599 (81-470) (NRAM_I63A3)search Influenza A virus (A/duck/Ukraine/1/1963(H3N8))search < 90% 390 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q07599 (81 - 470) Neuraminidase Influenza A virus

Chain Structural classification (CATH) Sequence family (Pfam)
A Neuraminidasesearch Neuraminidasesearch
Chain InterPro annotation
A Glycoside hydrolase, family 34search Sialidasessearch