2hr7 Summary

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Insulin receptor (domains 1-3)

The structure was published by Lou, M., Garrett, T.P., McKern, N.M., et al., Cosgrove, L.J., Frenkel, M.J., and Ward, C.W., in 2006 in a paper entitled "The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.32 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Insulin receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin receptor P06213 (28-512) (INSR_HUMAN)search Homo sapienssearch < 90% 486 95%
B Insulin receptor P06213 (28-512) (INSR_HUMAN)search Homo sapienssearch < 90% 486 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06213 (28 - 512) Insulin receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1search, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2search Furin-like cysteine rich regionsearch, Receptor L domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P06213) transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch membranesearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Receptor L-domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch