› 2hoa

Solution NMR

STRUCTURE DETERMINATION OF THE ANTP(C39->S) HOMEODOMAIN FROM NUCLEAR MAGNETIC RESONANCE DATA IN SOLUTION USING A NOVEL STRATEGY FOR THE STRUCTURE CALCULATION WITH THE PROGRAMS DIANA, CALIBA, HABAS AND GLOMSA

Released:
DOI: 10.2210/pdb2hoa/pdb
PDB entry 2hoa coloured by chain, ensemble of 20 models, front view.
PDB entry 2hoa coloured by chain, ensemble of 20 models, side view.
PDB entry 2hoa coloured by chain, ensemble of 20 models, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure determination of the Antp (C39----S) homeodomain from nuclear magnetic resonance data in solution using a novel strategy for the structure calculation with the programs DIANA, CALIBA, HABAS and GLOMSA.
Güntert P, Qian YQ, Otting G, Müller M, Gehring W, Wüthrich K
J Mol Biol 217 531-40 (1991)
PMID: 1671604

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181610 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homeobox domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 8.66 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7KSY7 (Residues: 280-346; Coverage: 19%)
Gene names: 3.4, ANT-C, ANT-P, ANTC, ANTP, Ant, AntP, AntP1, Antp, Antp P1, Antp P2, Antp1, Aus, BG:DS07700.1, CG1028, DMANTPE1, DRO15DC96Z, DmAntp, Dmel\CG1028, Dmel_CG1028, Hu, Ns, Scx, antp, l(3)84Ba
Sequence domains: Homeodomain
Structure domains: Homeodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Homeodomain-DNA recognition.
Gehring et al. (1994)
4 more

1 mention without citation

Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins.
Wang et al. (2023)